Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions

The mammalian target of rapamycin (mTOR) correlates with cell survival under hypoxia and regulates hypoxia-inducible factor-1α (HIF-1α), a key protein in hypoxia-related events. However, the role of mTOR in radio-resistance has not been fully investigated. Therefore, the effect of mTOR on the radio-...

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Veröffentlicht in:J Radiat Res
Hauptverfasser: Ushijima, Hiroki, Suzuki, Yoshiyuki, Oike, Takahiro, Komachi, Mayumi, Yoshimoto, Yuya, Ando, Ken, Okonogi, Noriyuki, Sato, Hiro, Noda, Shin-ei, Saito, Jun-ichi, Nakano, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497394/
https://ncbi.nlm.nih.gov/pubmed/25887043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrv021
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