Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis

INTRODUCTION: Type 17 T helper cells and interleukin (IL)-17 play important roles in the pathogenesis of human and murine arthritis. Although there is a clear link between IL-17 and granulocyte macrophage colony-stimulating factor (GM-CSF) in the inflammatory cascade, details about their interaction...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: van Nieuwenhuijze, Annemarie E. M., van de Loo, Fons A., Walgreen, Birgitte, Bennink, Miranda, Helsen, Monique, van den Bersselaar, Liduine, Wicks, Ian P., van den Berg, Wim B., Koenders, Marije I.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496892/
https://ncbi.nlm.nih.gov/pubmed/26081345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0683-5
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