Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

Contactin-associated protein-like 2 (Caspr2), also known as CNTNAP2, is a cell adhesion molecule that clusters voltage-gated potassium channels (Kv1.1/1.2) at the juxtaparanodes of myelinated axons and may regulate axonal excitability. As a component of the Kv1 complex, Caspr2 has been identified as...

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Pubblicato in:Front Cell Neurosci
Autori principali: Pinatel, Delphine, Hivert, Bruno, Boucraut, José, Saint-Martin, Margaux, Rogemond, Véronique, Zoupi, Lida, Karagogeos, Domna, Honnorat, Jérôme, Faivre-Sarrailh, Catherine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496579/
https://ncbi.nlm.nih.gov/pubmed/26217189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00265
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