Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A(165) overexpression in transgenic mice and amelioration of tumor formation by miR-16

Many studies have shown that vascular endothelial growth factor (VEGF), especially the human VEGF-A(165) (hVEGF-A(165)) isoform, is a key proangiogenic factor that is overexpressed in lung cancer. We generated transgenic mice that overexpresses hVEGF-A(165) in lung-specific Clara cells to investigat...

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Publicado en:Oncotarget
Autores principales: Tung, Yu-Tang, Huang, Pin-Wu, Chou, Yu-Ching, Lai, Cheng-Wei, Wang, Hsiu-Po, Ho, Heng-Chien, Yen, Chih-Ching, Tu, Chih-Yen, Tsai, Tung-Chou, Yeh, Dah-Cherng, Wang, Jiun-Long, Chong, Kowit-Yu, Chen, Chuan-Mu
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496351/
https://ncbi.nlm.nih.gov/pubmed/25912305
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