Surface density-induced pleating of a lipid monolayer drives nascent high density lipoprotein assembly

Biogenesis of high density lipoproteins (HDL) is coupled to the transmembrane protein, ATP-binding cassette transporter A1 (ABCA1), which transports phospholipid (PL) from the inner to the outer membrane monolayer. Using a combination of computational and experimental approaches, we show that increa...

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Publicado en:Structure
Main Authors: Segrest, Jere P., Jones, Martin K., Catte, Andrea, Manchekar, Medha, Datta, Geeta, Zhang, Lei, Zhang, Robin, Li, Ling, Patterson, James C., Palgunachari, Mayakonda N., Oram, Jack F., Ren, Gang
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496276/
https://ncbi.nlm.nih.gov/pubmed/26095027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.05.010
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