A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis

Here we showed that ursolic acid (UA), a pentacyclic triterpene natural product, and its novel prodrug derivative US597 suppressed cancer cells adhesion, invasion and migration. This effect was accompanied by inhibition of focal adhesion signaling pathway including alterations in ICAM-1, VCAM-1, E-s...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Xiang, Liping, Chi, Ting, Tang, Qiao, Yang, Xiang, Ou, Minrui, Chen, Xiufen, Yu, Xiaobo, Chen, Jianzhong, Ho, Rodney J.Y., Shao, Jingwei, Jia, Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496218/
https://ncbi.nlm.nih.gov/pubmed/25823660
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