FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15

FBXW7 mutations occur in a variety of human cancers including colorectal cancer (CRC). Elucidating its mechanism of action has become crucial for cancer therapy; however, it is also complicated by the fact that FBXW7 can influence many pathways due to its role as an E3-ubiquitin ligase in proteasome...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Ningning, Lorenzi, Federica, Kalakouti, Eliana, Normatova, Makhliyo, Babaei-Jadidi, Roya, Tomlinson, Ian, Nateri, Abdolrahman S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496214/
https://ncbi.nlm.nih.gov/pubmed/25860929
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