Screening for FtsZ Dimerization Inhibitors Using Fluorescence Cross-Correlation Spectroscopy and Surface Resonance Plasmon Analysis

FtsZ is an attractive target for antibiotic research because it is an essential bacterial cell division protein that polymerizes in a GTP-dependent manner. To find the seed chemical structure, we established a high-throughput, quantitative screening method combining fluorescence cross-correlation sp...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mikuni, Shintaro, Kodama, Kota, Sasaki, Akira, Kohira, Naoki, Maki, Hideki, Munetomo, Masaharu, Maenaka, Katsumi, Kinjo, Masataka
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496089/
https://ncbi.nlm.nih.gov/pubmed/26154290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130933
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