Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer’s disease

Amyloid beta (Aβ) is implicated in Alzheimer’s disease (AD) as an integral component of both neural toxicity and plaque formation. Brains of the longest-lived rodents, naked mole-rats (NMRs) approximately 32 years of age, had levels of Aβ similar to those of the 3xTg-AD mouse model of AD. Interestin...

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Pubblicato in:Neurobiol Aging
Autori principali: Edrey, Yael H., Medina, David X., Gaczynska, Maria, Osmulski, Pawel A., Oddo, Salvatore, Caccamo, Antonella, Buffenstein, Rochelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496028/
https://ncbi.nlm.nih.gov/pubmed/23618870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.03.032
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