A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice

BACKGROUND: Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS). METHODOLOGY: Here we describe a conjugate vaccine for choler...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Sayeed, Md. Abu, Bufano, Meagan Kelly, Xu, Peng, Eckhoff, Grace, Charles, Richelle C., Alam, Mohammad Murshid, Sultana, Tania, Rashu, Md. Rasheduzzaman, Berger, Amanda, Gonzalez-Escobedo, Geoffrey, Mandlik, Anjali, Bhuiyan, Taufiqur Rahman, Leung, Daniel T., LaRocque, Regina C., Harris, Jason B., Calderwood, Stephen B., Qadri, Firdausi, Vann, W. F., Kováč, Pavol, Ryan, Edward T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495926/
https://ncbi.nlm.nih.gov/pubmed/26154421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003881
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