FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance

FGF21 is a key metabolic regulator modulating physiological processes and its pharmacological administration improves metabolic profile in preclinical species and humans. We used native-FGF21 and a long-acting FGF21 (PF-05231023), to determine the contribution of liver and brown adipose tissue (BAT)...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bernardo, Barbara, Lu, Min, Bandyopadhyay, Gautam, Li, Pingping, Zhou, Yingjiang, Huang, Jie, Levin, Nancy, Tomas, Eva M., Calle, Roberto A., Erion, Derek M., Rolph, Timothy P., Brenner, Martin, Talukdar, Saswata
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495598/
https://ncbi.nlm.nih.gov/pubmed/26153793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11382
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