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RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1
RalA and RalB proteins are key mediators of oncogenic Ras signaling in human oncogenesis. Herein we investigated the mechanistic contribution of Ral proteins to invasion of lung cancer A549 cells after induction of epithelial-mesenchymal transition (EMT) with TGFβ. We show that TGFβ-induced EMT prom...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495419/ https://ncbi.nlm.nih.gov/pubmed/26152517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11759 |
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