Increasing Avermectin Production in Streptomyces avermitilis by Manipulating the Expression of a Novel TetR-Family Regulator and Its Target Gene Product

Avermectins produced by Streptomyces avermitilis are commercially important anthelmintic agents. The detailed regulatory mechanisms of avermectin biosynthesis remain unclear. Here, we identified SAV3619, a TetR-family transcriptional regulator designated AveT, to be an activator for both avermectin...

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Bibliografiske detaljer
Udgivet i:Appl Environ Microbiol
Main Authors: Liu, Wenshuai, Zhang, Qinling, Guo, Jia, Chen, Zhi, Li, Jilun, Wen, Ying
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495205/
https://ncbi.nlm.nih.gov/pubmed/26002902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00868-15
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