Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice

Intense effort has been devoted to understanding predisposition to chronic systemic inflammation as this contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) in mice (KODMAC) is sufficient to induce insulin resistance by promoting M2 macroph...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Oh, Jisu, Riek, Amy E., Darwech, Isra, Funai, Katsuhiko, Shao, JianSu, Chin, Kathleen, Sierra, Oscar L., Carmeliet, Geert, Ostlund, Richard E., Bernal-Mizrachi, Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495012/
https://ncbi.nlm.nih.gov/pubmed/25801026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.043
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