Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

The hepatitis B virus (HBV)-X protein (HBx) induces malignant transformation of liver cells, and elevated expression of alpha-fetoprotein (AFP) is a significant biomarker of hepatocarcinogenesis. However, the role of AFP in HBV-related hepatocarcinogenesis is unclear. In this study, we investigated...

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Udgivet i:Oncotarget
Main Authors: Zhu, Mingyue, Guo, Junli, Li, Wei, Lu, Yan, Fu, Shigan, Xie, Xieju, Xia, Hua, Dong, Xu, Chen, Yi, Quan, Ming, Zheng, Shaojiang, Xie, Keping, Li, Mengsen
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494932/
https://ncbi.nlm.nih.gov/pubmed/25682869
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