Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer of thyroid C-cells, for which few treatment options are available. We have recently reported a role for cyclin-dependent kinase 5 (CDK5) in MTC pathogenesis. We have generated a mouse model, in which MTC proliferation is induced upon condi...

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Publicado en:Oncotarget
Autores principales: Pozo, Karine, Hillmann, Antje, Augustyn, Alexander, Plattner, Florian, Hai, Tao, Singh, Tanvir, Ramezani, Saleh, Sun, Xiankai, Pfragner, Roswitha, Minna, John D., Cote, Gilbert J., Chen, Herbert, Bibb, James A., Nwariaku, Fiemu E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494924/
https://ncbi.nlm.nih.gov/pubmed/25900242
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