AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

Lactic acid generated by highly glycolytic tumours is exported by the MonoCarboxylate Transporters, MCT1 and MCT4, to maintain pHi and energy homeostasis. We report that MCT1 inhibition combined with Mct4 gene disruption severely reduced glycolysis and tumour growth without affecting ATP levels. Bec...

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Publicat a:Oncotarget
Autors principals: Pelletier, Joffrey, Roux, Danièle, Viollet, Benoit, Mazure, Nathalie M., Pouysségur, Jacques
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Priority Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494908/
https://ncbi.nlm.nih.gov/pubmed/26059436
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