Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

BACKGROUND: Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We undertook hotspot sequencing of 50 genes commonly mutated in human cancer acros...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Mackenzie, Robertson, Kommoss, Stefan, Winterhoff, Boris J., Kipp, Benjamin R., Garcia, Joaquin J., Voss, Jesse, Halling, Kevin, Karnezis, Anthony, Senz, Janine, Yang, Winnie, Prigge, Elena-Sophie, Reuschenbach, Miriam, Doeberitz, Magnus Von Knebel, Gilks, Blake C., Huntsman, David G., Bakkum-Gamez, Jamie, McAlpine, Jessica N., Anglesio, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494777/
https://ncbi.nlm.nih.gov/pubmed/25986173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1421-8
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