Antimalarial Activity of Natural and Synthetic Prodiginines

Prodiginines are a family of linear and cyclic oligopyrrole red-pigmented compounds. Herein we describe the in vitro antimalarial activity of 4 natural (IC(50) = 1.7-8.0 nM) and 3 sets of synthetic prodiginines against Plasmodium falciparum. Set 1 compounds replaced the terminal non-alkylated pyrrol...

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Publicat a:J Med Chem
Autors principals: Papireddy, Kancharla, Smilkstein, Martin, Kelly, Jane Xu, Shweta, Salem, Shaimaa M., Alhamadsheh, Mamoun, Haynes, Stuart W., Challis, Gregory L., Reynolds, Kevin A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494750/
https://ncbi.nlm.nih.gov/pubmed/21736388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200543y
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