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Revealing Three Stages of DNA-Cisplatin Reaction by a Solid-State Nanopore

The dynamic structural behavior in DNA due to interaction with cisplatin is essential for the functionality of platinum-based anti-cancer drugs. Here we report a novel method to monitor the interaction progress in DNA-cisplatin reaction in real time with a solid-state nanopore. The interaction proce...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhou, Zhi, Hu, Ying, Shan, Xinyan, Li, Wei, Bai, Xuedong, Wang, Pengye, Lu, Xinghua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493569/
https://ncbi.nlm.nih.gov/pubmed/26148968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11868
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