Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration

CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM, endothelial cell (EC) CD99 activates protein kinase A (PKA) via a signaling complex formed with the lysine-rich juxtamembrane cytoplasmic tail of...

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Vydáno v:J Exp Med
Hlavní autoři: Watson, Richard L., Buck, Jochen, Levin, Lonny R., Winger, Ryan C., Wang, Jing, Arase, Hisashi, Muller, William A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493416/
https://ncbi.nlm.nih.gov/pubmed/26101266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150354
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