Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH signaling, we sequenced and profiled a large...

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Xehetasun bibliografikoak
Argitaratua izan da:Cancer Cell
Egile Nagusiak: Kool, Marcel, Jones, David T.W., Jäger, Natalie, Northcott, Paul A., Pugh, Trevor J., Hovestadt, Volker, Piro, Rosario M., Esparza, L. Adriana, Markant, Shirley L., Remke, Marc, Milde, Till, Bourdeaut, Franck, Ryzhova, Marina, Sturm, Dominik, Pfaff, Elke, Stark, Sebastian, Hutter, Sonja, Şeker-Cin, Huriye, Johann, Pascal, Bender, Sebastian, Schmidt, Christin, Rausch, Tobias, Shih, David, Reimand, Jüri, Sieber, Laura, Wittmann, Andrea, Linke, Linda, Witt, Hendrik, Weber, Ursula D., Zapatka, Marc, König, Rainer, Beroukhim, Rameen, Bergthold, Guillaume, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Schmidt, Sabine, Wolf, Stephan, Lawerenz, Chris, Bartholomae, Cynthia C., von Kalle, Christof, Unterberg, Andreas, Herold-Mende, Christel, Hofer, Silvia, Kulozik, Andreas E., von Deimling, Andreas, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Hasselblatt, Martin, Crawford, John R., Grant, Gerald A., Jabado, Nada, Perry, Arie, Cowdrey, Cynthia, Croul, Sydney, Zadeh, Gelareh, Korbel, Jan O., Doz, Francois, Delattre, Olivier, Bader, Gary D., McCabe, Martin G., Collins, V. Peter, Kieran, Mark W., Cho, Yoon-Jae, Pomeroy, Scott L., Witt, Olaf, Brors, Benedikt, Taylor, Michael D., Schüller, Ulrich, Korshunov, Andrey, Eils, Roland, Wechsler-Reya, Robert J., Lichter, Peter, Pfister, Stefan M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493053/
https://ncbi.nlm.nih.gov/pubmed/24651015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.02.004
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