The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure

Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation. The disease is characterized by mild somatic features and severe neurological disorders. Very little is known on the cardiac dy...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Schiattarella, Gabriele Giacomo, Cerulo, Giuliana, De Pasquale, Valeria, Cocchiaro, Pasquale, Paciello, Orlando, Avallone, Luigi, Belfiore, Maria Paola, Iacobellis, Francesca, Di Napoli, Daniele, Magliulo, Fabio, Perrino, Cinzia, Trimarco, Bruno, Esposito, Giovanni, Di Natale, Paola, Pavone, Luigi Michele
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493027/
https://ncbi.nlm.nih.gov/pubmed/26147524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131662
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