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Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington’s Disease (HD) and Spinocerebellar Ataxias (SCAs)
In humans, neurodegenerative disorders such as Huntington’s disease (HD) and many spinocerebellar ataxias (SCAs) have been found to be associated with CAG trinucleotide repeat expansion. An important RNA-mediated mechanism that causes these diseases involves the binding of the splicing regulator pro...
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| Vydáno v: | PLoS One |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4493008/ https://ncbi.nlm.nih.gov/pubmed/26148061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131788 |
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