The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells

Koelreuteria henryi Dummer, an endemic plant of Taiwan, has been used as a folk medicine for the treatment of hepatitis, enteritis, cough, pharyngitis, allergy, hypertension, hyperlipidemia, and cancer. Austrobailignan-1, a natural lignan derivative isolated from Koelreuteria henryi Dummer, has anti...

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Publicat a:PLoS One
Autors principals: Wu, Chun-Chi, Huang, Keh-Feng, Yang, Tsung-Ying, Li, Ya-Ling, Wen, Chi-Luan, Hsu, Shih-Lan, Chen, Tzu-Hsiu
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492957/
https://ncbi.nlm.nih.gov/pubmed/26147394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132052
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