Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide

We have previously reported that Smad6, one of the inhibitory Smads of transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signaling, inhibits Toll-like receptor (TLR) 4 signaling by disrupting the Pellino-1-mediated TLR4 signaling complex. Here, we developed Smaducin-6, a novel me...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Lee, Youn Sook, Park, Jin Seok, Jung, Su Myung, Kim, Sang-Doo, Kim, Jun Hwan, Lee, Jae Young, Jung, Kyeong Cheon, Mamura, Mizuko, Lee, Sangho, Kim, Seong-Jin, Bae, Yoe-Sik, Park, Seok Hee
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492818/
https://ncbi.nlm.nih.gov/pubmed/25766838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404653
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