Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells

There has been intensive effort to identify in vivo biomarkers that can be used to monitor drug-induced kidney damage and identify injury before significant impairment occurs. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and human macrophage colony stimulating...

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Veröffentlicht in:Pharmacol Res Perspect
Hauptverfasser: Huang, Johnny X, Kaeslin, Geraldine, Ranall, Max V, Blaskovich, Mark A, Becker, Bernd, Butler, Mark S, Little, Melissa H, Lash, Lawrence H, Cooper, Matthew A
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492764/
https://ncbi.nlm.nih.gov/pubmed/26171227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.148
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