Superior Immunologic and Therapeutic Efficacy of a Xenogeneic Genetic Cancer Vaccine Targeting Carcinoembryonic Human Antigen

We have generated a xenogeneic vaccine against human carcinoembryonic antigen (hCEACAM-5 or commonly hCEA) using as immunogen rhesus CEA (rhCEA). RhCEA cDNA was codon-usage optimized (rhCEAopt) and delivered by sequential DNA electro-gene-transfer (DNA-EGT) and adenoviral (Ad) vector. RhCEAopt was c...

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Vydáno v:Hum Gene Ther
Hlavní autoři: Aurisicchio, Luigi, Roscilli, Giuseppe, Marra, Emanuele, Luberto, Laura, Mancini, Rita, La Monica, Nicola, Ciliberto, Gennaro
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492738/
https://ncbi.nlm.nih.gov/pubmed/25869226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2014.141
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