DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6

Spinocerebellar ataxia type 6 (SCA6) belongs to the family of CAG/polyglutamine (polyQ)-dependent neurodegenerative disorders. SCA6 is caused by abnormal expansion in a CAG trinucleotide repeat within exon 47 of CACNA1A, a bicistronic gene that encodes α1A, a P/Q-type calcium channel subunit and a C...

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Publicat a:Hum Mol Genet
Autors principals: Tsou, Wei-Ling, Hosking, Ryan R., Burr, Aaron A., Sutton, Joanna R., Ouyang, Michelle, Du, Xiaofei, Gomez, Christopher M., Todi, Sokol V.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492400/
https://ncbi.nlm.nih.gov/pubmed/25954029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv174
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