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Formylglycine, a Post-Translationally Generated Residue with Unique Catalytic Capabilities and Biotechnology Applications

Formylglycine (fGly) is a catalytically essential residue found almost exclusively in the active sites of type I sulfatases. Formed by post-translational oxidation of cysteine or serine side chains, this aldehyde-functionalized residue participates in a unique and highly efficient catalytic mechanis...

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Pubblicato in:ACS Chem Biol
Autori principali: Appel, Mason J., Bertozzi, Carolyn R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492166/
https://ncbi.nlm.nih.gov/pubmed/25514000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500897w
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