Chinese Hamster Ovary (CHO) Host Cell Engineering to Increase Sialylation of Recombinant Therapeutic Proteins by Modulating Sialyltransferase Expression

N-Glycans of human proteins possess both α2,6- and α2,3-linked terminal sialic acid (SA). Recombinant glycoproteins produced in Chinese hamster overy (CHO) only have α2,3-linkage due to the absence of α2,6-sialyltransferase (St6gal1) expression. The Chinese hamster ST6GAL1 was successfully overexpre...

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Publicat a:Biotechnol Prog
Autors principals: Lin, Nan, Mascarenhas, Joaquina, Sealover, Natalie R., George, Henry J., Brooks, Jeanne, Kayser, Kevin J., Gau, Brian, Yasa, Isil, Azadi, Parastoo, Archer-Hartmann, Stephanie
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492121/
https://ncbi.nlm.nih.gov/pubmed/25641927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.2038
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