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OZONE EXPOSURE INITIATES A SEQUENTIAL SIGNALING CASCADE IN AIRWAYS INVOLVING INTERLEUKIN-1BETA RELEASE, NERVE GROWTH FACTOR SECRETION, AND SUBSTANCE P UPREGULATION
Previous studies demonstrated that interleukin-1β (IL-1β) and nerve growth factor (NGF) increase synthesis of substance P (SP) in airway neurons both after ozone (O(3)) exposure and by direct application. It was postulated that NGF mediates O(3)-induced IL-1β effects on SP. The current study specifi...
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| Publicado no: | J Toxicol Environ Health A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491938/ https://ncbi.nlm.nih.gov/pubmed/25734767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15287394.2014.971924 |
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