Recombinant human hemoglobins designed for gene therapy of sickle cell disease.

Two human hemoglobins designed to inhibit the polymerization of sickle hemoglobin (Hb S; alpha 2 beta S2) have been produced. Mutations that disrupt the ability of Hb S to form polymers were introduced into the normal human beta-globin gene by site-specific mutagenesis. These mutations affect the ax...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	McCune, S L, Reilly, M P, Chomo, M J, Asakura, T, Townes, T M
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937904/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.21.9852
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