DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter

INTRODUCTION: Sclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes’ hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is not well known. Based on our previous findings on the interaction between Wnt/β-...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Papathanasiou, Ioanna, Kostopoulou, Fotini, Malizos, Konstantinos N., Tsezou, Aspasia
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491261/
https://ncbi.nlm.nih.gov/pubmed/26071314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0674-6
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