Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

INTRODUCTION: Events normally taking place in the terminal chondrocyte differentiation in the growth plate are also observed during osteoarthritis (OA) development, suggesting that molecules, such as Wnts and bone morphogenetic proteins (BMPs) regulating chondrocyte activity in the growth plate, may...

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Autors principals: Papathanasiou, Ioanna, Malizos, Konstantinos N, Tsezou, Aspasia
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446456/
https://ncbi.nlm.nih.gov/pubmed/22513174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3805
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