Bone morphogenetic protein-2-induced Wnt/β-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

INTRODUCTION: Events normally taking place in the terminal chondrocyte differentiation in the growth plate are also observed during osteoarthritis (OA) development, suggesting that molecules, such as Wnts and bone morphogenetic proteins (BMPs) regulating chondrocyte activity in the growth plate, may...

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Главные авторы: Papathanasiou, Ioanna, Malizos, Konstantinos N, Tsezou, Aspasia
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446456/
https://ncbi.nlm.nih.gov/pubmed/22513174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3805
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