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Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages
BACKGROUND: Under inflammatory conditions or during tumor progression macrophages acquire distinct phenotypes, with factors of the microenvironment such as hypoxia and transforming growth factor β (TGFβ) shaping their functional plasticity. TGFβ is among the factors causing alternative macrophage ac...
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| Publicat a: | Cell Biosci |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491253/ https://ncbi.nlm.nih.gov/pubmed/26146544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-015-0026-x |
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