Pulmonary Hypertension after Prolonged Hypoxic Exposure in Mice with a Congenital Deficiency of Cyp2j

Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to the regulation of pulmonary vascular tone and hypoxic pulmonary vasoconstriction. We investigated whether the attenuated acute vasoconstrictor response to hypoxic exposure of Cyp2j(−/−) mice would protect these mice against...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Beloiartsev, Arkadi, da Glória Rodrigues-Machado, Maria, Zhou, Guo Ling, Tan, Timothy C., Zazzeron, Luca, Tainsh, Robert E., Leyton, Patricio, Jones, Rosemary C., Scherrer-Crosbie, Marielle, Zapol, Warren M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2015
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491134/
https://ncbi.nlm.nih.gov/pubmed/25233285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0482OC
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