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Neonatal Basophils Stifle the Function of Early Life Dendritic Cells to Curtail T Helper 1 Immunity in Newborn Mice
Neonatal immunity exhibits weak Th1 but excessive Th2 responses and the underlying mechanisms remain elusive. Here, we show that neonatal basophils readily produce IL-4, a cytokine that proved to be pivotal in shaping the programs of both lymphocyte subsets. Besides promoting Th2 programs, IL-4 is c...
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| Publicado en: | J Immunol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4491044/ https://ncbi.nlm.nih.gov/pubmed/26034171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500027 |
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