Histone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma

Histone variants are emerging as key regulatory molecules in cancer. Here we report a novel role for the H2A.Z isoform H2A.Z.2 as a driver of malignant melanoma. H2A.Z.2 is highly expressed in metastatic melanoma, correlates with decreased patient survival, and is required for cellular proliferation...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Vardabasso, Chiara, Gaspar-Maia, Alexandre, Hasson, Dan, Pünzeler, Sebastian, Valle-Garcia, David, Straub, Tobias, Keilhauer, Eva C., Strub, Thomas, Dong, Joanna, Panda, Taniya, Chung, Chi-Yeh, Yao, Jonathan L., Singh, Rajendra, Segura, Miguel F., Fontanals-Cirera, Barbara, Verma, Amit, Mann, Matthias, Hernando, Eva, Hake, Sandra B., Bernstein, Emily
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490946/
https://ncbi.nlm.nih.gov/pubmed/26051178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.05.009
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