Inhibition of intracerebral glioblastoma growth by targeting the insulin-like growth factor 1 receptor involves different context-dependent mechanisms

BACKGROUND: Signaling by insulin-like growth factor 1 receptor (IGF-1R) can contribute to the formation and progression of many diverse tumor types, including glioblastoma. We investigated the effect of the IGF-1R blocking antibody IMC-A12 on glioblastoma growth in different in vivo models. METHODS:...

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Publicado en:Neuro Oncol
Autores principales: Zamykal, Martin, Martens, Tobias, Matschke, Jakob, Günther, Hauke S., Kathagen, Annegret, Schulte, Alexander, Peters, Regina, Westphal, Manfred, Lamszus, Katrin
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490867/
https://ncbi.nlm.nih.gov/pubmed/25543125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou344
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