Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

During T-cell development, Cd8 expression is controlled via dynamic regulation of its cis-regulatory enhancer elements. Insufficiency of enhancer activity causes variegated Cd8 expression in CD4 (+)CD8 (+) double-positive (DP) thymocytes. Brd1 is a subunit of the Hbo1 histone acetyltransferase (HAT)...

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Publicado no:Nat Commun
Main Authors: Mishima, Yuta, Wang, Changshan, Miyagi, Satoru, Saraya, Atsunori, Hosokawa, Hiroyuki, Mochizuki-Kashio, Makiko, Nakajima-Takagi, Yaeko, Koide, Shuhei, Negishi, Masamitsu, Sashida, Goro, Naito, Taku, Ishikura, Tomoyuki, Onodera, Atsushi, Nakayama, Toshinori, Tenen, Daniel G., Yamaguchi, Naoto, Koseki, Haruhiko, Taniuchi, Ichiro, Iwama, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490789/
https://ncbi.nlm.nih.gov/pubmed/25519988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6872
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