Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation

BACKGROUND: Aggregated forms of amyloid-β (Aβ) peptides are important triggers for microglial activation, which is an important pathological component in the brains of Alzheimer’s patients. Cu(II) ions are reported to be coordinated to monomeric Aβ, drive Aβ aggregation, and potentiate Aβ neurotoxic...

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Publicado en:J Neuroinflammation
Autores principales: Yu, Fengxiang, Gong, Ping, Hu, Zhuqin, Qiu, Yu, Cui, Yongyao, Gao, Xiaoling, Chen, Hongzhuan, Li, Juan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490619/
https://ncbi.nlm.nih.gov/pubmed/26104799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0343-3
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