Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies

Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpressi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Moilanen, Anu-Maarit, Riikonen, Reetta, Oksala, Riikka, Ravanti, Laura, Aho, Eija, Wohlfahrt, Gerd, Nykänen, Pirjo S., Törmäkangas, Olli P., Palvimo, Jorma J., Kallio, Pekka J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490394/
https://ncbi.nlm.nih.gov/pubmed/26137992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12007
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