Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies

Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpressi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Moilanen, Anu-Maarit, Riikonen, Reetta, Oksala, Riikka, Ravanti, Laura, Aho, Eija, Wohlfahrt, Gerd, Nykänen, Pirjo S., Törmäkangas, Olli P., Palvimo, Jorma J., Kallio, Pekka J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490394/
https://ncbi.nlm.nih.gov/pubmed/26137992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados