Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response

The inhibition of p53 activity by histone deacetylase 3 (HDAC3) has been reported, but the precise molecular mechanism is unknown. Here we show that programmed cell death 5 (PDCD5) selectively mediates HDAC3 dissociation from p53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degr...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Choi, Hyo-Kyoung, Choi, Youngsok, Park, Eun Sung, Park, Soo-Yeon, Lee, Seung-Hyun, Seo, Jaesung, Jeong, Mi-Hyeon, Jeong, Jae-Wook, Jeong, Jae-Ho, Lee, Peter C. W., Choi, Kyung-Chul, Yoon, Ho-Geun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490383/
https://ncbi.nlm.nih.gov/pubmed/26077467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8390
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