A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia

AIMS: Depressed sarcoplasmic reticulum (SR) Ca(2+) cycling, a universal characteristic of human and experimental heart failure, may be associated with genetic alterations in key Ca(2+)-handling proteins. In this study, we identified a novel PLN mutation (R25C) in dilated cardiomyopathy (DCM) and inv...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Liu, Guan-Sheng, Morales, Ana, Vafiadaki, Elizabeth, Lam, Chi Keung, Cai, Wen-Feng, Haghighi, Kobra, Adly, George, Hershberger, Ray E., Kranias, Evangelia G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490203/
https://ncbi.nlm.nih.gov/pubmed/25852082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv127
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