NUAK2 amplification coupled with PTEN deficiency promote melanoma development via CDK activation

The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes but its therapeutic utility has yet to be confirmed. In this study, we show how its genetic amplication in PTEN-deficient melanomas may rationalize the use of CDK2 inhibitors as a therapeutic strategy. Analysi...

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Publicado en:Cancer Res
Autores principales: Namiki, Takeshi, Yaguchi, Tomonori, Nakamura, Kenta, Valencia, Julio C., Coelho, Sergio G., Yin, Lanlan, Kawaguchi, Masakazu, Vieira, Wilfred D., Kaneko, Yasuhiko, Tanemura, Atsushi, Katayama, Ichiro, Yokozeki, Hiroo, Kawakami, Yutaka, Hearing, Vincent J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490056/
https://ncbi.nlm.nih.gov/pubmed/25832654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3209
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