Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 α(2)β(2) Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA

[Image: see text] The metabolism of host cholesterol by Mycobacterium tuberculosis (Mtb) is an important factor for both its virulence and pathogenesis, although how and why cholesterol metabolism is required is not fully understood. Mtb uses a unique set of catabolic enzymes that are homologous to...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Yang, Meng, Lu, Rui, Guja, Kip E., Wipperman, Matthew F., St. Clair, Johnna R., Bonds, Amber C., Garcia-Diaz, Miguel, Sampson, Nicole S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489319/
https://ncbi.nlm.nih.gov/pubmed/26161441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/id500033m
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