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The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions

In response to neurodegeneration, the adult mammalian brain activates a cellular cascade that results in reactive astro- and microgliosis. The mechanism through which astrocytes become reactive and the physiological consequences of their activation in response to neurodegeneration is complex. While...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Pitter, Kenneth L., Tamagno, Ilaria, Feng, Xi, Ghosal, Kaushik, Amankulor, Nduka, Holland, Eric C., Hambardzumyan, Dolores
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489138/
https://ncbi.nlm.nih.gov/pubmed/24895267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22702
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