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Temperature-based on-column solute focusing in capillary liquid chromatography reduces peak broadening from precolumn dispersion and volume overload when used alone or with solvent-based focusing

On-column focusing is essential for satisfactory performance using capillary scale columns. On-column focusing results from generating transient conditions at the head of the column that lead to high solute retention. Solvent-based on-column focusing is a well-known approach to achieve this. Tempera...

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Pubblicato in:J Chromatogr A
Autori principali: Groskreutz, Stephen R., Horner, Anthony R., Weber, Stephen G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488902/
https://ncbi.nlm.nih.gov/pubmed/26091787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2015.05.071
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